Recombinant Human TIMP-1

Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes.¹ TIMP-1 is a novel negative regulator of HGF activity during liver regeneration.² Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.³

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Cys24

Lyophilized

The predicted molecular weight of Recombinant Human TIMP-1 is Mr 20.6 kDa. However, the actual molecular weight as observed by migration onSDS-PAGE is Mr 28-30 kDa.

20.6

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at -20°C to -70°C for three months in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Denhardt, DT.et al. (2005) Breat Cancer Res Treat. 94: 185
2. Khokha, R. et al. (2005) Hepatology 41: 857
3. Chen, X. et al. (2008) Nephrology Dialysis Transportation 23: 1861