Anti-Human CD86- PE
Anti-Human CD86- PE
Product No.: C1537
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Clone 37301 Target CD86 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names B7-2 Isotype IgG1 Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Formulation This monoclonal antibody is conjugated to R-phycoerythrin (R-PE) and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative. Storage and Handling This R-phycoerythrin (R-PE) conjugate is stable for at least twelve months when stored at 2-8°C protected from light. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (488 nm) and/or Green Laser (532 nm)/Yellow-Green Laser (561 nm) RRIDAB_2828606 Applications and Recommended Usage? Quality Tested by Leinco Flow Cytometry: This conjugate has been pre-diluted to use approximately 10 µl per test when staining cells for flow cytometry. A typical test sample constitutes approximately 50 µl of packed whole blood or 1 x 106 continuous passage or activated cell cultures that have been centrifuged at 500 X g for five minutes and resuspended in 200-400 µl of 1X PBS. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 37301 recognizes an epitope on human CD86. Background CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells. Antigen Distribution CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. Ligand/Receptor CD28, CD152 PubMed NCBI Gene Bank ID UniProt.org References & CitationsTechnical Protocols Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
