Anti-Group A Streptococcal Polysaccharide – Purified No Carrier Protein

Group A Streptococcal Polysaccharide

This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Liquid

Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -80°C. Avoid Repeated Freeze Thaw Cycles.

Research Use Only

2 – 8° C Wet Ice

Clone 2S1.3 specifically targets the polysaccharide antigens present on the surface of Group A Streptococcus (GAS) bacteria.

Streptococcus bacteria are a type of gram-positive bacteria that are classified into different groups based on their serological characteristics. Among them, Group A and Group B Streptococcus are particularly important for medical purposes, as they can cause serious infections^{1, 2}. Group A Streptococcus is a genus of gram-positive bacteria that can cause both pathogenic and commensal infections. These bacteria are particularly significant in medicine because they can lead to severe infections, including pharyngitis, scarlet fever, and rheumatic fever³.

When it comes to diagnosing streptococcal infections, monoclonal antibodies such as Clone 2S1.3 play an important role. This antibody is used to detect specific anti-polysaccharide antibodies in patients with streptococcal infections. The clone has been studied using enzyme immunoassay (EIA) and passive hemagglutination reaction (PHR) to detect specific anti-polysaccharide antibodies and has shown a broad spectrum of antibody titers⁴. In the case of streptococcal infections, monoclonal antibodies such as Clone 2S1.3 can help doctors diagnose the infection more accurately and provide more targeted treatment to patients.

Group A Streptococcus bacteria commonly colonize mucosal surfaces such as the mouth, nares, and pharynx in humans and animals like horses, pigs, and cows. They can also be found on the skin, heart, or muscle tissue under certain conditions.

1. Riesen WF, Skvaril F, Braun DG. Scand J Immunol. 1976;5(4):383-390.
2. Widdowson JP, Maxted WR, Pinney AM. J Med Microbiol. 1976;9(1):73-88.
3. Steer AC, Danchin MH, Carapetis JR. J Paediatr Child Health. 2007;43(4):203-213.
4. Burova LA, Gladilina MM, Semykina LV, Murashov SV. Vestn Akad Med Nauk SSSR. 1989;(11):12-17.
5. Root-Bernstein R. Front Pediatr. 2014;2:85.
6. Barrett DJ, Triggiani M, Ayoub EM. J Clin Microbiol. 1983;18(3):622-627.
7. Ruch FE, Smith L. J Clin Microbiol. 1982;16(1):145-152.
8. Gupta R, Rattan A, Prakash K, Talwar GP, Gupta S. The Indian journal of medical research. Published online 1993. Accessed February 1, 2024.