Anti-Human CD62E (E-Selectin) – FITC
Anti-Human CD62E (E-Selectin) – FITC
Product No.: C675
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Clone 1.2B6 Target CD62E Formats AvailableView All Product Type Monoclonal Antibody Alternate Names SELE, CD62E, Endothelial Leukocyte Adhesion Molecule (ELAM), ELAM1, ESEL, LECAM2 Isotype IgG1 Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen TNF-Activated Human Umbilical Vein Endothelial Cells Formulation This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative. Storage and Handling Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year. Country of Origin USA Shipping Next Day Ambient Excitation Laser Blue Laser (488 nm) RRIDAB_2829817 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human E-Selectin (Clone 1.2B6) recognizes an epitope on Human E-Selectin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.1 E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.2 E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.3 E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.4 Antigen DetailsLigand/Receptor Siayl Lewis X (CD15s) and PSGL-1 (CD162) bind to CD62E. Recently, CLA (cutaneous lymphocyte antigen) has also been reported in interact with CD62E PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Milstone D et al. (2004) PNAS 101: 8005
2. Dimitroff CJ et al. (2009) J Visualized Experiments
3. Takako Hirata et al. (2005) J Immunol. 175: 8042
4. Ramakrishnan Vanitha et al. (2003) Cancer Res. 63: 6387
Technical Protocols |
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Prod No. | Description |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.