Recombinant Rat E-Selectin

E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.¹ E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.² E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.³ E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.⁴

Fc Fusion Protein

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Trp22

Lyophilized

The predicted molecular weight of Recombinant Rat E-Selectin is Mr 78 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 110-120 kDa.

78

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Milstone, D. et al. (2004) PNAS 101: 8005
2. Dimitroff, CJ. et al. (2009) J Visualized Experiments
3. Hirata, T.et al. (2005) J Immunol. 175: 8042
4. Vanitha, R. et al. (2003) Cancer Res. 63: 6387