Anti-Imipramine Library Pack [3 Clones]
Data
Activity Assay * Determined by radial immunodiffusion for several lots of ascites. **ELISA is an indirect assay against imipramine conjugated to BSA on the solid phase. Titers represent endpoint dilutions that achieve absorbance values > 0.1.
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DescriptionBackground Imipramine is a prominent, first-generation tricyclic antidepressant (TCA) belonging to the dibenzazepine group. Historically one of the first major antidepressants developed, it is primarily prescribed for the treatment of major depressive disorders and childhood enuresis. Imipramine functions by inhibiting the reuptake of neurotransmitters—specifically serotonin and norepinephrine—in the central nervous system, thereby elevating mood and alleviating depressive symptoms. Due to its narrow therapeutic index and the potential for severe side effects or toxicity at high doses, precise monitoring of imipramine levels in patient samples is highly critical for both patient safety and therapeutic efficacy. The Role of Imipramine Antibodies in Toxicology and TDMBecause TCAs like imipramine are frequently involved in clinical overdose scenarios, rapid and accurate detection methods are essential. Anti-imipramine monoclonal antibodies are widely utilized by diagnostic manufacturers and clinical researchers in: - Therapeutic Drug Monitoring (TDM): Ensuring that a patient's systemic drug levels remain within the strict therapeutic window to prevent toxicity or sub-therapeutic dosing. - Toxicology Screening: Facilitating the rapid detection of TCA levels in urine, serum, or plasma samples for emergency room diagnostics or forensic toxicology. - Pharmacokinetic Research: Assisting pharmaceutical developers in tracing the metabolism and physiological distribution of imipramine and its active metabolites in pre-clinical studies. The Advantage of an Antibody Library Pack When developing novel diagnostics, finding the optimal antibody is rarely a one-size-fits-all process. The Anti-Imipramine Antibody Library Pack provides researchers with a curated panel of diverse, highly specific mouse monoclonal clones. - Testing multiple clones side-by-side allows assay developers to empirically determine the best-performing antibodies for their specific platform. This library pack is designed to help researchers. - Screen for Competitive Binders: Identify the clone with the ideal affinity and displacement characteristics for competitive immunoassay formats. - Evaluate Cross-Reactivity: Test multiple clones to map epitope recognition and ensure minimal cross-reactivity with other TCAs, unrelated drugs, or specific imipramine metabolites (such as desipramine). - Optimize Assay Sensitivity: Select the clone that provides the highest signal-to-noise ratio and lowest limit of detection (LOD) in your specific matrix (e.g., urine, plasma, or serum). Immunogen Imipramine conjugated to KLH. Specificity Selection of Mouse Monoclonal antibodies specific to Imipramine. Product Preparation Streamlining Immunoassay Development: Originally developed by QED Bioscience and available through Leinco Technologies, all clones in this library pack are highly purified and rigorously tested. Supplied in a carrier-free phosphate-buffered saline (PBS) format without added preservatives, these antibodies are ready for immediate downstream conjugation. Kit DetailsMaterials Provided Anti-Imipramine Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies: 16051 - Anti-Imipramine Mouse Monoclonal Antibody - Clone IM11-214.1 - Isotype IgM 16052 - Anti-Imipramine Mouse Monoclonal Antibody - Clone IM12-342.3 - Isotype IgG2b 16053 - Anti-Imipramine Mouse Monoclonal Antibody - Clone IM12-379.2 - Isotype IgG2b Storage & Stability These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Technical Protocols |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
