Recombinant Human BMP-13

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Pricing & Details

Product. No.B423
Alternate Names
GDF-6, Cartilage-Derived Morphogenetic Protein 2 [CDMP-2]
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
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B423-50 µg
50 µg
$379.00
In stock
Max:
Min: 1
Step: 1

Background

Bone Morphogenetic Protein-13 (BMP-13) is a member of the transforming growth factor beta (TGF-beta) superfamily of growth factors that may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins and control eye development. The biological actions of BMP-13 remain poorly understood. Expression of BMP-13 is predominantly seen in hypertrophic chondrocytes in regions of endochondral bone formation during development. BMP-13 in post natal articular cartilage suggests that this protein may function in an autocrine/paracrine way to regulate the growth and maintenance of articular cartilage. In addition to this BMP-13 has been shown to induce neotendon/neoligament formation when injected on a collagen carrier subcutaneously or intramuscularly. This indicates that BMP-13 may have therapeutic value for tendon or ligament healing following injury.

At the amino acid sequence level, human and mouse GDF-6 are 99% identical. GDF-6 response is mediated by the formation of hetero-oligomeric complexes of type I (BMPR-IB) and type II (BMPR-II or Activin R-II) sereine/threonine kinase receptors, and the activation of Smad proteins.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells1 in the range of 2.0-3.0 µg/ml.
Expression Host
E. coli
Protein Accession No.
P43028
Amino Acid Sequence
tafasr hgkrhgkksr lrcsrkplhv nfkelgwddw iiapleyeay hcegvcdfpl rshleptnha iiqtlmnsmd pgstppsccv ptkltpisil yidagnnvvy kqyedmvves cgcr
N-terminal Sequence Analysis
Thr335
State of Matter
Solution
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human BMP-13 is 13.7 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a solution of 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Country of Origin
USA
Shipping
Dry Ice
NCBI Gene Bank

References & Citations

1. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
B423
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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