Recombinant Human CCL16

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Pricing & Details

Prod. No.L124
Expression Host
E. coli
Size
Price
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25 µg
219.00
Max:
Min: 1
Step: 1

Background

Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.1 Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. CCL16 is a potent maturation factor for monocyte-derived DCs (MoDCs) through differential use of its four receptors and an indirect regulator of Th cell differentiation.2 CCL16 play a role in hepatic vascular formation during development and in angiogenesis associated to hepatic diseases.3

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
qpkvpew vntpstcclk yyekvlprrl vvgyrkalnc hlpaiifvtk rnrevctnpn ddwvqeyikd pnlpllptrn lstvkiitak ngqpqllnsq
N-terminal Sequence Analysis
Gln24
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CCL16 is Mr 11 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Kwon, BS. et al.(1998) Biochem. Biophys. Res. Commun. 247(2): 217-22
2. Giovarelli, M. et al.(2006) J. Immunol. 177: 6143
3. Bussolino, F. et al.(2004) Blood 103: 40
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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