Recombinant Human CCL16

Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.¹ Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. CCL16 is a potent maturation factor for monocyte-derived DCs (MoDCs) through differential use of its four receptors and an indirect regulator of Th cell differentiation.² CCL16 play a role in hepatic vascular formation during development and in angiogenesis associated to hepatic diseases.³

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Gln24

Lyophilized

The predicted molecular weight of Recombinant Human CCL16 is Mr 11 kDa.

11

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Kwon, BS. et al.(1998) Biochem. Biophys. Res. Commun. 247(2): 217-22
2. Giovarelli, M. et al.(2006) J. Immunol. 177: 6143
3. Bussolino, F. et al.(2004) Blood 103: 40