Recombinant Human CD22 (Extracellular Domain)
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BackgroundCluster of differentiation 22 also known as CD22 is a B-cell-restricted transmembrane protein, which acts as a negative regulator of B-cell signalling. CD22 also has lectin-like adhesive properties.1 CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."2 Protein DetailsPurity >98% by SDS Page and HPLC Endotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity The biological activity of Human sCD22 was determined by its ability to inhibit Raji cell proliferation. The expected ED<sub>50</sub>=15µg/ml. State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Human sCD22 is Mr 135 kDa. Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient References & Citations1. Crocker PR et al. (2000) Immunol. 101: 342
2. Tsubata T et al. (2008) J Immunol. 180: 907 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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