Recombinant Human EDA-A2

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Pricing & Details

Product. No.E223
Alternate Names
Ectodysplasin-A2, Tabby
Expression Host
NS0 cells
Species
Human
Prod No.
Size
Price
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Qty
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E223-10 µg
10 µg
$365.00
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Min: 1
Step: 1
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Background

Ectodysplasin A (EDA) is a ligand of the tumor necrosis factor (TNF) family that has been shown to play a crucial role in ectodermal differentiation. EDA-A1 and EDA-A2 are the two main splice variants of EDA. 1 EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). EDA-A1 and EDA-A2 are differentially expressed and play a role in epidermal morphogenesis.
EDA-A2 is a type III integral membrane protein with three CYS region at the N terminal region. 2 EDA-A2 may be a promising agent for the gene therapy of osteosarcoma.

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Fusion Protein Tag
Histidine Tag
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
mhhhhhhhhh hgggsgggsg ggsiegragp pgpngppgpp gppgpqgppg ipgipgipgt tvmgppgppg ppgpqgppgl qgpsgaadka gtrenqpavv hlqgqgsaiq vkndlsggvl ndwsritmnp kvfklhprsg elevlvdgty fiysqvyyin ftdfasyevv vdekpflqct rsietgktny ntcytagvcl lkarqkiavk mvhadisinm skhttffgai rlgeapas
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human EDA-A2 is Mr 24.7 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 28-38 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Chaudhary, PM. et al.(2004)Protein Expr Purif 37:162
2. Dixit, VM. et al.(2000)Science 290:523
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
E223
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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