Recombinant Human FGF-17

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Pricing & Details

Product. No.F126
Alternate Names
FGFHFibroblast Growth Factor-17, FGF-13
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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F126-25 µg
25 µg
$279.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

Fibroblast growth factor 17, also known as FGF17 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-17 is most similar to FGF-8 and is highly conserved between mouse and human (93 % identity).1,2 FGF17 is required for several complex social behaviors and studies suggest that disturbances in FGF17 signaling may contribute to neuropsychiatric diseases that affect such behaviors.3

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human FGF-17 was determined by its ability to stimulate 3H-thymidine incorporation by NR6R-3T3 fibroblast. The expected ED50 for this effect is typically 15 - 60 ng/ml, in the presence of 1 μg/ml heparin.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
tqgenhpspn fnqyvrdqga mtdqlsrrqi reyqlysrts gkhvqvtgrr isataedgnk faklivetdt fgsrvrikga esekyicmnk rgkligkpsg kskdcvftei vlennytafq narhegwfma ftrqgrprqa srsrqnqrea hfikrlyqgq lpfpnhaekq kqfefvgsap trrtkrtrrp qplt
N-terminal Sequence Analysis
Thr23 (with and without an N-terminal Met)
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human FGF-17 is Mr 22.6 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is 21.5 and 22.6 kDa (reducing conditions).
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Hoshikawa, M. et al. (1998) Biochemical and Biophysical Research Communications 244: 187
2. Xu, J. et al. (1999) Mechanisms of Development 83: 165
3. Mucke, L. et al. (2008) Genes Brain Behav. 7: 344
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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