BackgroundGrowth differentiation factor 5 (cartilage-derived morphogenetic protein-1), also known as GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. GDF5 is expressed in the developing central nervous system.1
It increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.2
Protein DetailsPurity >95% by SDS Page and HPLC Endotoxin Level <0.125 EU/µg Biological Activity Human GDF-5 is fully biologically active when compared to standard.
Induction of alkaline phosphatase acrtivity in ATDC5 cells: EC50 = 40Nm. Expression Host E. coli Protein Accession No. Amino Acid Sequence APSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Sullivan, A. et al. (2004) J Neurocytol 33: 479 2. O'Keeffe, G. et al. (2005) J Anat 207: 219 IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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