Recombinant Human Glia Maturation Factor β

Glial maturation factor-beta (GMF-beta) is isolated from brain tissues.¹The expression of GMF-beta is largely limited to the brain², especially glial cells and some neurons.³ GMF-beta is involved in the phenotypic differentiation of glial cells and neurons. It is expressed in the cytosol and on the cell surface of astrocytes.^4,5 It is not secreted and presumably acts at short distances involving cell-to-cell interactions with target cells expressing a receptor. It is suggested that induction of GMF-beta expression in the kidney may play a key role in renal disease progression caused by proteinuria.

SESLVVCDVA EDLVEKLRKF RFRKETNNAA IIMKIDKDKR LVVLDEELEG ISPDELKDEL PERQPRFIVY SYKYQHDDGR VSYPLCFIFS SPVGCKPEQQ MMYAGSKNKL VQTAELTKVF EIRNTEDLTE EWLREKLGFF H

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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1. Lim, R. et al. (1989) Proceedings of the National Academy of Sciences (USA)86: 390
2. Lim, R. et al. (1986) Cancer Research 46: 5241
3. Wang, BR et al. (1992) Brain Research 591: 1
4. Zaheer, A et al. (1993) Journal of Neurochemistry 60: 914
5. Lim, R. et al. (1990) Cell Regulation 1: 741
6. Lim, R. et al. (1990) Proceedings of the National Academy of Sciences (USA) 87: 5233