Recombinant Human IL-1 RI

Recombinant Human IL-1 RI

Product No.: I-556

[product_table name="All Top" skus="I-556"]

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Alternate Names
Interleukin-1 Receptor Type I, IL1R1, CD121A, D2S1473, IL-1R-Alpha, IL1R, IL1RA, P80
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Select Product Size
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Interleukin-1 receptor, type I (IL1R1), also known as CD121a, is a transmembrane glycoprotein and member of the IL-1 receptor family. As important mediators involved in many immune and inflammatory responses, the agonists IL-1α and IL-1β bind to IL1R1, leading to the signal transduction and activation of NF-κ B. IL1R1 also forms a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 which is indispensible for the signaling processes (1). IL1R1 has been shown to interact with PIK3R1, Myd88 and IL1RAP (2-4). It is expressed predominantly by T cells, fibroblasts and endothelial cells.

Protein Details

>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence
dkckereeki ilvssaneid vrpcplnpne hkgtitwykd dsktpvsteq asrihqhkek lwfvpakved sghyycvvrn ssyclrikis akfvenepnl cynaqaifkq klpvagdggl vcpymeffkn ennelpklqw ykdckpllld nihfsgvkdr livmnvaekh rgnytchasy tylgkqypit rviefitlee nkptrpvivs panetmevdl gsqiqlicnv tgqlsdiayw kwngsvided dpvlgedyys venpankrrs tlitvlnise iesrfykhpf tcfaknthgi daayiqliyp vt
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-1 RI is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 55 kDa.
Predicted Molecular Mass
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Burns, K. et al. (2006) Curr. Biol. 16:2265
2. Reddy, SA. et al. (1995) J. Biol. Chem. 272:29167
3. Burns, K. et al. (2000) Nat. Cell Biol. 2:346
4. Huang, J. et al. (1997) Proc. Natl. Acad. Sci. (USA) 94:12829
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.