Recombinant Human IL-1 RII

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Pricing & Details

Product. No.I-555
Alternate Names
Interleukin-1 Receptor Type II, IL1R2, CD121b, IL1RB, MGC47725
Expression Host
Sf 21 Insect Cells
Species
Human
Prod No.
Size
Price
Avail.
Qty
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I-555-50 µg
50 µg
$439.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin 1 receptor type II (IL1R2), also known as CD121b, is a transmembrane protein and member of the IL-1 receptor family. It is found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Like IL1R1, IL1R2 can bind all three forms of IL-1 (IL-1α, IL-1β and IL-1RA) but does not transmit IL-1 signals.1 In addition to the membrane-bound form, IL1R2 also exists as the soluble form and either acts as a decoy receptor that inhibits IL-1 action by blocking the binding of IL-1 to the type I receptor complex.2 Furthermore, IL-4 is reported to antagonize the activity of IL-1 by inducing the expression and release of IL1R2. Recombinant soluble IL1R2 is thus a potent antagonist of IL-1 action and serves as a potential therapeutic target.3 IL1R2 is involved in the control of the pro-inflammatory state that takes place in the endometrium during the premenstrual and menstrual periods. IL1R2 can neutralize IL-1β and counteract its effect on endometrial stromal cells, and therefore may provide a new clinical strategy for the treatment of endometriosis.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
<1.0 EU/µg as determined by the LAL method
Expression Host
Sf 21 Insect Cells
Protein Accession No.
Amino Acid Sequence
ftlqpaa htgaarscrf rgrhykrefr legepvalrc pqvpywlwas vsprinltwh kndsartvpg eeetrmwaqd galwllpalq edsgtyvctt rnasycdkms ielrvfentd aflpfisypq iltlstsgvl vcpdlseftr dktdvkiqwy kdsllldkdn ekflsvrgtt hllvhdvale dagyyrcvlt fahegqqyni trsielrikk kkeetipvii splktisasl gsrltipckv flgtgtpltt mlwwtandth iesaypggrv tegprqeyse nnenyievpl ifdpvtredl hmdfkcvvhn tlsfqtlrtt vke
N-terminal Sequence Analysis
Phe14
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-1 RII is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 40 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. McMahan, CJ. et al. (1991) Embo. J. 10:2821
2. Colotta, F. et al. (1993) Science 261:472
3. Neumann, D. et al. (2000) J. Immunol. 165:3350
4. Akoum, A. et al. (2005) Hum. Rep. 20:1177
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
I-555
I-569
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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