Recombinant Human IL-17B

Home/Recombinant Proteins/Recombinant Human IL-17B

Pricing & Details

Product. No.I-237
Alternate Names
Interleukin-17B, CX1, NIRF [Neuronal Interleukin-17-Related Factor, Neuronal IL17-Related Factor], Zcyto7, IL20, Cytokine-Like Protein ZCYTO7, Interleukin-17 Beta, IL-17B, MGC138900, MGC138901
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-237-25 µg
25 µg
$359.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin-17B, also known as IL-17B, Cytokine CX1 and NIRF, belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17B is expressed by T cells and stimulates the release of TNF-alpha and IL1-beta in the monocytic cell line, THP-1. It does not induce expression of IL1-alpha, IL-6, IFN-gamma or G-CSF in these cells (1-2). IL-17B is known to stimulate the proliferation of chondrocytes, bone and is highly expressed in nervous tissue, resulting in repair of diseased tissue. It is expressed highly in spinal cord and at lower levels in brain, pancreas, small intestine, lung and stomach (1). Expression of the IL-17B receptor (Evi27) appears to be restricted to human kidney, pancreas, liver, brain, and intestines. IL-17B, either alone or in combination with other cytokines or growth factors is known to aid wound healing (3).

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-17B was determined by its ability to bind with rhIL-17B R/Fc in a functional ELISA.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
m qprspkskrk gqgrpgplap gphqvpldlv srmkpyarme eyernieemv aqlrnssela qrkcevnlql wmsnkrslsp wgysinhdps ripvdlpear clclgcvnpf tmqedrsmvs vpvfsqvpvr rrlcpppprt gpcrqravme tiavgctcif
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-17B is Mr 18.3 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in sodium dihydrogen phosphate (NaH2PO4) and sodium chloride (NaCl).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Li, H. et al. (2000) Proc. Nat. Acad. Sci. (USA) 97:773
2. Shi, Y. et al. (2000) J. Biol. Chem. 275:19167
3. Kokubu, T. et al. (2008) J. Histochem. Cytochem. 56:89
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Leinco Technologies uses cookies to improve your experience and our website service. By continuing to browse our website, you accept our cookie policy. Ok