Recombinant Human IL-17F

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Pricing & Details

Product. No.I-200
Alternate Names
ML1, LOC112744
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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I-200-25 µg
25 µg
$224.00
In stock
Max:
Min: 1
Step: 1
I-200-100 µg
100 µg
$512.00
In stock
Max:
Min: 1
Step: 1
I-200-500 µg
500 µg
$1,949.00
In stock
Max:
Min: 1
Step: 1
I-200-1 mg
1 mg
$3,214.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Background

IL-17F is a homodimeric protein that is a member of the IL17 family of cytokines produced by activated T-cells and monocytes.1 IL-17F is expressed by activated T cells and can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover.2 IL-17F is an important regulator of inflammatory responses that function differently than IL-17 in immune responses and diseases.3

Protein Details

Purity
>97% by SDS Page and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-17F was determined by its ability to bind mIL-17 RC in a functional ELISA with an estimated KD < 3 nM.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
The DNA sequence encoding the mature mouse IL-17F (Arg 21 - Ala 153) was inserted into a suitable expression vector and was expressed in E. coli (Hurst, S.D. et al., 2002, J. Immunol. 169(1):443 - 453).
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-17F is Mr 15 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Starnes T. et al. (2001) J. of Immonol. 167: 4137 2. Starovasnik MA. et al. (2001) Embo J. 20: 5332 3. Chen Dong et al. (2008) J Experimental Med. 205: 1063
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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