Recombinant Human IL-3 Rα

Interleukin 3 receptor alpha (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a type I transmembrane protein that is expressed on the large majority of progenitor cells. IL-3R alpha function can be defined by the activity of its ligand interleukin-3. IL-3 is a multipotent cytokine that promotes the development of hemopoietic progenitors into cells of the erythroid, myeloid and lymphoid lineages.¹ CD123 may be a promising strategy for the preferential ablation of acute myelogenous leukemia (AML) cells.²

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Lys20

Lyophilized

The predicted molecular weight of Recombinant Human IL-3 Rα is Mr 33 kDa.

33

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Garnache-Ottou, F. et al. (2015) Haematologica. 100(2):223-30
2. Phillips, GL. et al. (2000) Leukemia 14: 1777