Recombinant Human MSP

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Pricing & Details

Product. No.M1238
Alternate Names
HGF-Like Protein, Scatter Factor-2, MST1 (Macrophage Stimulating 1)
Expression Host
NS0 cells
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
M1238-10 µg
10 µg
$309.00
In stock
Max:
Min: 1
Step: 1
M1238-50 µg
50 µg
$939.00
In stock
Max:
Min: 1
Step: 1

Background

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like, is serum protein with homology to hepatocyte growth factor (HGF).1 MSP is a soluble cytokine that belongs to the family of the plasminogen-related growth factors (PRGFs). PRGFs are alpha/beta heterodimers that bind to transmembrane tyrosine kinase receptors. Through binding to its receptor, MSP stimulates dissociation of epithelia and works as an inflammatory mediator by repressing the production of nitric oxide (NO).2 MSP exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury.3

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Expression Host
NS0 cells
Protein Accession No.
AAA59872
Amino Acid Sequence
qr splndfqvlr gtelqhllha vvpgpwqedv adaeecagrc gplmdcrafh ynvsshgcql lpwtqhspht rlrrsgrcdl fqkkdyvrtc imnngvgyrg tmattvgglp cqawshkfpn dhkytptlrn gleenfcrnp dgdpggpwcy ttdpavrfqs cgikscreaa cvwcngeeyr gavdrtesgr ecqrwdlqhp hqhpfepgkf ldqglddnyc rnpdgserpw cyttdpqier efcdlprcgs eaqprqeatt vscfrgkgeg yrgtanttta gvpcqrwdaq iphqhrftpe kyackdlren fcrnpdgsea pwcftlrpgm raafcyqirr ctddvrpqdc yhgageqyrg tvsktrkgvq cqrwsaetph kpqftftsep haqleenfcr npdgdshgpw cytmdprtpf dycalrrcad dqppsildpp dqvqfekcgk rvdrldqrrs klrvvgghpg nspwtvslrn rqgqhfcggs lvkeqwilta rqcfsschmp ltgyevwlgt lfqnpqhgep slqrvpvakm vcgpsgsqlv llklersvtl nqrvaliclp pewyvvppgt kceiagwget kgtgndtvln vaflnvisnq ecnikhrgrv resemctegl lapvgacegd yggplacfth ncwvlegiii pnrvcarsrw pavftrvsvf vdwihkvmrl g
N-terminal Sequence Analysis
Gln19 predicted &
State of Matter
Lyophilized
Predicted Molecular Mass
This protein consists of a disulfide-linked heterodimer. The predicted molecular mass is 78.5 kDa (MSPα/β), 53.3 kDa (α chain), and 25.2 kDa (β chain). The actual molecular mass of Recombinant Human HGF is Mr 81 kDa, 62 kDa, and 30 kDa under reducing conditions.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in sodium phosphate (NaH2PO4) and sodium chloride (NaCl).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Suda, T. et al. (1997) J Clin. Invest. 9: 701
2. Paolo, M. et al. (2001) Molecular Biol. Of Cell 12: 1341
3. Camussi, G. et al. (2008) J Am Soc Nephrol. 19: 1904
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
M1238
M1306
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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