Nephroblastoma overexpressed gene, also known as NOV is a member of the CCN (connective tissue growth factor [CTGF]) family of proteins. These proteins are cysteine-rich and are noted for having growth-regulatory functions.1 NOV is highly expressed in the nervous system.2 NOV is a specific cell fate regulator in the myogenic lineage, acting negatively on key myogenic genes thus controlling the transition from progenitor cells to myoblasts.3 NOV also supports endothelial cell adhesion and angiogenesis through interactions with integrins.4
>95% by SDS Page and HPLC
<0.1 EU/µg as determined by the LAL method
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human NOV is Mr 37.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Maki RA. et al. (1999) Gene 238: 471 2. Kleinman HK. et al. (2003) FASEB J. 17: 1919 3. Dubois C. et al. (2006) Exp Cell Resp. 312: 1876 4. Martinerie C. et al. (2005) Cell Commun Adhes. 12: 41
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.