Recombinant Human TSLP

Home/Recombinant Proteins/Recombinant Human TSLP

Pricing & Details

Product. No.T142
Alternate Names
Thymic Stromal Lymphopoietin
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
T142-10 µg
10 µg
$359.00
In stock
Max:
Min: 1
Step: 1

Data

Background

Thymic stromal lymphopoietin (TSLP) is an IL-7-like epithelial cell-derived cytokine that supports differentiation and long-term growth of B cells (1). It is expressed in the heart, liver, testis and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5 but uses kinases other than the JAKs for activation. It activates DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation (2-3). TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (4).

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
Data not yet available.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
myd ftncdfekik aaylstiskd litymsgtks tefnntvscs nrphclteiq sltfnptagc aslakemfam ktkaalaiwc pgysetqina tqamkkrrkr kvttnkcleq vsqlqglwrr fnrpllkqq
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TSLP is Mr 15 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Alpers, CE. et al. (2001) Am. J. Pathol. 159:2355
2. Ziegler, SF. et al. (2007) Annu. Rev. Immunol. 25:193
3. Ziegler, SF. et al. (2005) Nat. Immunol. 6:1047
4. Gilliet, M. et al. (2003) J. Exp. Med. 197:1059
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Leinco Technologies uses cookies to improve your experience and our website service. By continuing to browse our website, you accept our cookie policy. Ok