Recombinant Human VEGF121 (a.a. 207-327)

Recombinant Human VEGF121 (a.a. 207-327)

Product No.: V113

[product_table name="All Top" skus="V113"]

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Alternate Names
Vascular endothelial growth factor 121, VEGFA, MGC70609, VPF, VAS, Folliculostellate Cell-Derived Growth Factor, Glioma-Derived Endothelial Cell Mitogen
Product Type
Recombinant Protein
Expression Host
E. coli Cells

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Vascular endothelial growth factor (VEGF), a potent proangiogenic cytokine1 is the key signal used by oxygen-hungry cells to promote growth of blood vessels. It binds to specialized receptors on the surfaces of endothelial cells and directs them to build new vessels.2 The alternative splicing of mRNA from a single 8-exon VEGFA gene results in multiple isoforms which are classified by their terminal exon splice site. The classification depends on whether this terminal exon (exon-8) is proximal or distal. VEGF121 refers to the proximal splice site. VEGF are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angiogenesis). Abnormal VEGF function is associated with inflammatory diseases including atherosclerosis, and hyperthyroidism.3,4,5,6

Protein Details

>95% by SDS Page and analyzed by silver stain.
Endotoxin Level
<0.01EU/µg as determined by the LAL method
Protein Accession No.
N-terminal Sequence Analysis
Met & Pro208
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human VEGF-121 is Mr 14 kDa.
Predicted Molecular Mass
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Folkman, J. et al. (2008) FASEB J. 22: 3728
2. Goodsell, DS. et al. (2002) The Oncologist 7: 569
3. Mugishima, H. et al. (2006) J Atheroscler Thromb. 13: 130
4. Claesson-Welsh, L. et al. (2006) Exp Cell Res. 312: 549
5. Claesson-Welsh, L. et al. (1999) Trends Biochem Sci. 28: 488
6. Ellis, LM. et al. (2005) J Clin Oncol. 23: 1011
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.