Recombinant Human VEGF-B

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Pricing & Details

Product. No.V127
Alternate Names
Vascular Endothelial Growth Factor-B, VEGFL, VRF
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
Add to cart
V127-25 µg
25 µg
$349.00
In stock
Max:
Min: 1
Step: 1

Background

Vascular endothelial growth factor B (VEGF-B) is a member of the VEGF family and particularly abundant in heart and skeletal muscle.1 It is an angiogenic and neuroprotective protein that reduces hypoxic and ischemic neuronal injury.2 VEGF-B has a role in vascularization of the heart, skeletal muscles and developing bones, and in paracrine interactions between endothelial and surrounding muscle cells.3 VEGF-B also regulates lipid metabolism.4

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human VEGF-B was determined by its binding ability in a functional ELISA. Immobilized recombinant rat Neuropilin1 at 4 μg/ml (100 μl/well) can bind recombinant human VEGFB 167 with a linear range of 0.3-20 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
pvsqpdapg hqrkvvswid vytratcqpr evvvpltvel mgtvakqlvp scvtvqrcgg ccpddglecv ptgqhqvrmq ilmirypssq lgemsleehs qcecrpkkkd savkpdsprp lcprctqhhq rpdprtcrcr crrrsflrcq grglelnpdt crcrklrr
N-terminal Sequence Analysis
Pro22
State of Matter
Solution
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human VEGF-B is Mr 19 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is 19-22 kDa (reducing conditions).
Formulation
This recombinant protein was 0.2 μm filtered and is supplied as a solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
The protein should be stored at -20 - -70°C upon receipt. It may be stored at 2 - 8°C for one month. However, it is recommended to aliquot into working volumes and store at -20 - -70°C in a manual defrost freezer. Avoid repeat freeze thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
PubMed
NCBI Gene Bank

References & Citations

1. Eriksson, U. et al. (1993) Proc Natl Acad Sci USA 93: 2576
2. Greenberg, DA. et al. (2006) Dev Biol. 289: 329
3. Eriksson, U. et al. (1999) Dev Dyn. 215: 12
4. Alitalo, K. et al. (2008) Circ Res. 103: 1018
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
V127
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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