Recombinant Mouse IFNγ

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Pricing & Details

Product. No.I-217
Alternate Names
Interferon Gamma, Immune Interferon, Type II Interferon, T Cell Interferon, MAF, IFNG, IFG, IFI
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
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I-217-100 µg
100 µg
$429.00
In stock
Max:
Min: 1
Step: 1

Background

Interferon-gamma (IFN-γ) or type II interferon is a dimerized soluble cytokine that is the only member of the type II class of interferons.1 It is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.2 IFN-γ has antiviral, immunoregulatory, and anti-tumour properties.3

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse Interferon-Gamma was measured in an anti-viral assay using L-929 cells infected with EMC virus.1 The expected ED50 for this effect is 0.3 - 0.9 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
hgtviesles lnnyfnssgi dveekslfld niwrnwqkdg dmkilqsqii sfylrlfevl kdnqaisnni svieshlitt ffsnskakkd afmsiakfev nnpqvqrqaf nelirvvhql lpesslrkrk rsrc
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IFN-γ is Mr 15.6 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 11-12 kDa (reducing conditions).
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) with trehalose pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Soong, L. et al. (2004) Infect Immun.72(2):988-95. PubMed
2. Goeddel, DV. et al. (1982) Nature 298: 859
3. Wilson, CB. et al. (2007) Adv. Immunol. 96: 41
4. Hume, DA. et al. (2004) J Leukoc Biol. 75: 163
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
I-217
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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