Recombinant Mouse IL-22

Recombinant Mouse IL-22

Product No.: I-273

[product_table name="All Top" skus="I-273"]

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Alternate Names
Interleukin-22, ZcytoR11, CRF2-9, IL-TIF
Product Type
Recombinant Protein
Expression Host
E. coli Cells

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IL-22 is a 20 kD cytokine and a member of the IL-10 superfamily. This protein binds to a heterodimeric cell surface receptor comprised of IL-10R2 and IL-22R1 subunits which results in the activation of JAK1, Tyk2, and MAP kinases and transcription factors, most notably STAT3. IL-22 is generated by immune cells and incites non-immune cells to regulate local tissue inflammation. Additionally, IL-22 participates in both wound healing and in protection against microbes. IL-22 primarily takes effect on stromal and epithelial cells via stimulating cell survival, proliferation and synthesis of antimicrobials. Furthermore, IL-22 is an IL-10 homologue and, like IL-10, supports the survival of both hepatocytes in the liver and epithelial cells in the lung and gut. The pathogenesis of several autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis and psoriasis, can be attributed to IL-22 dysregulation.

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells.<sup>4</sup> The ED<sub>50</sub> for this effect is 60-300 pg/mL.
Protein Accession No.
Amino Acid Sequence
Mouse IL-22 protein Leu34-Val179, with an N-terminal Met
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse IL-22 is Mr 16.5 kDa.
Predicted Molecular Mass
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient

References & Citations

1. Yssel, H. et al. (2002) Int. Immunol. 14: 1351
2. Polikarpov, I. et al. (2006) Vitam Horm. 74: 77
3. Morel F. et al. (2005) J. Immunol. 174: 3695
4. Nagalakshmi, ML. et al. (2004) Int Immunopharmacol. 4:679.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Prod No.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.