Recombinant Mouse IL-22

IL-22 is a 20 kD cytokine and a member of the IL-10 superfamily. This protein binds to a heterodimeric cell surface receptor comprised of IL-10R2 and IL-22R1 subunits which results in the activation of JAK1, Tyk2, and MAP kinases and transcription factors, most notably STAT3. IL-22 is generated by immune cells and incites non-immune cells to regulate local tissue inflammation. Additionally, IL-22 participates in both wound healing and in protection against microbes. IL-22 primarily takes effect on stromal and epithelial cells via stimulating cell survival, proliferation and synthesis of antimicrobials. Furthermore, IL-22 is an IL-10 homologue and, like IL-10, supports the survival of both hepatocytes in the liver and epithelial cells in the lung and gut. The pathogenesis of several autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis and psoriasis, can be attributed to IL-22 dysregulation.

Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells.⁴ The ED₅₀ for this effect is 60-300 pg/mL.

Mouse IL-22 protein Leu34-Val179, with an N-terminal Met

Met

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-22 is Mr 16.5 kDa.

16.5

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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2. Polikarpov, I. et al. (2006) Vitam Horm. 74: 77
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4. Nagalakshmi, ML. et al. (2004) Int Immunopharmacol. 4:679.