Recombinant Mouse MIP-2

Chemokine (C-X-C motif) ligand 2 (CXCL2) is an inducible murine chemokine involved in attraction of polymorphonuclear granulocytes to sites of infection.¹ This chemokine is secreted by monocytes and macrophages and is chemotactic for hematopoietic stem cells.^2,3,4

The biological activity of Mouse MIP-2 was determined by its ability to induce myeloperoxidase release from human neutrophils or chemotaxis of hCXCR2 transfected mouse BaF/3 cells. The expected ED₅₀ for these effects are typically 0.15 - 0.3 μg/ml or 0.1 - 0.5 ng/ml, respectively.

avv aselrcqclk tlprvdfkni qslsvtppgp hcaqteviat lkggqkvcld peaplvqkii qkilnkgkan

Ala28

Lyophilized

The predicted molecular weight of Recombinant Mouse CXCL2 is Mr 8 kDa.

8

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Beuscher, HU. et al. (2004) International Immunol. 16: 1675
2. Cerami, A. et al. (1989) Proc Nat Acad Sci. 86: 612
3. Grotendorst, GR. et al. (1990) Mol Cell Biol. 10: 5596
4. Fukuda, S. et al. (2006) Exp Hematol. 34: 1010