Recombinant Mouse/Rat MMP-2

Recombinant Mouse/Rat MMP-2

Product No.: M1255

[product_table name="All Top" skus="M1255"]

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Alternate Names
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Matrix metallopeptidase 2, also known as MMP2, is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-2 degrades type IV collagen, the major structural component of basement membranes and plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. MMP2 has been found to be associated with tumor invasion in various cancers.1

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Biological Activity
The specific activity, measured under the described conditions, is > 1,500 pmoles/min/μg.
Protein Accession No.
Amino Acid Sequence
iikfpgd vapktdkela vqylntfygc pkescnlfvl kdtlkkmqkf fglpqtgdld qntietmrkp rcgnpdvany nffprkpkwd knqityriig ytpdldpetv ddafaralkv wsdvtplrfs rihdgeadim infgrwehgd gypfdgkdgl lahafapgtg vggdshfddd elwtlgegqv vrvkygnadg eyckfpflfn greyssctdt grsdgflwcs ttynfekdgk ygfcphealf tmggnadgqp ckfpfrfqgt synscttegr tdgyrwcgtt edydrdkkyg fcpetamstv ggnsegapcv fpftflgnky esctsagrnd gkvwcatttn ydddrkwgfc pdqgyslflv aahefghamg lehsqdpgal mapiytytkn frlshddikg iqelygpspd adtdtgtgpt ptlgpvtpei ckqdivfdgi aqirgeifff kdrfiwrtvt prdkptgpll vatfwpelpe kidavyeapq eekavffagn eywvysastl ergypkplts lglppdvqqv daafnwsknk ktyifagdkf wrynevkkkm dpgfpkliad swnaipdnld avvdlqgggh syffkgayyl klenqslksv kfgsiksdwl gc
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse MMP-2 is Mr 71 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 72 kDa.
Predicted Molecular Mass
Supplied as a 0.2 μm filtered solution of 25 mM Tris, pH 7.5, 5 mM CaCl2, 75 mM NaCl, 0.025% Brij-35 and 50% glycerol at a concentration of 0.113 mg/ml.
Storage and Stability
This protein is stable for one month when stored sterile at -20°C or for three months when stored at -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day 2-8°C
NCBI Gene Bank

References & Citations

1. Viswanadha, VP. et al. (2017) J Cell Biochem. 118(9):2865-2876.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.