Recombinant Mouse SDF-1β
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BackgroundSDF-1 beta (stromal cell-derived factor-1 beta) is a non-glycosylated Polypeptide that is produced in E-Coli, belonging to the alpha chemokine (C-X-C) family of cytokines.1 SDF-1beta is a highly efficacious chemoattractant for resting lymphocytes and CD34(+) progenitor cells, and it efficiently blocks the CXCR-4-mediated entry into cells of T cell line tropic strains of HIV type 1 (HIV-1). SDF-1beta promotes HIV-1 replication and disease progression.2 Protein DetailsPurity >97% by SDS Page and HPLC Endotoxin Level <1.0 EU/µg Biological Activity The biological activity of Mouse Stromal Cell-Derived Factor-1 Beta is determined by its ability to chemoattract human monocytes using a concentration range of 50.0-100.0 ng/ml. Protein Accession No. P40224-2 Amino Acid Sequence KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Mouse SDF-1β is Mr 8.526 kDa. Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA References & Citations1. Muller HW et al. (2000) Eur J Neurosci. 12: 1857
2. Nagai Y et al. (1998) Proceedings of National Acad Sci USA 95: 6331
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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