Recombinant Rat MAG

Myelin-associated glycoprotein (MAG) is a transmembrane proteins that is a component of myelin in the central and peripheral nervous system.¹ It promotes neurite outgrowth during the embryonic development, but inhibits axonal regeneration in the adult nervous system.¹ MAG mediates cell-cell interactions between myelinating glial cells and neurons.² MAG as an important component of the myelin-derived inhibition of nerve regeneration. The acute loss of MAG function can promote significant axon growth across a site of CNS nerve damage.⁴

Fc Fusion Protein

g hwgawmpssi safegtcvsi pcrfdfpdel rpavvhgvwy fnspypknyp pvvfksrtqv vhesfqgrsr llgdlglrnc tlllstlspe lggkyyfrgd lggynqytfs ehsvldiint pnivvppevv agtevevscm vpdncpelrp elswlghegl geptvlgrlr edegtwvqvs llhfvptrea nghrlgcqaa fpnttlqfeg yasldvkypp vivemnssve aiegshvsll cgadsnpppl ltwmrdgmvl reavaeslyl dleevtpaed giyaclaena ygqdnrtvel svmyapwkpt vngtvvaveg etvsilcstq snpdpiltif kekqilatvi yesqlqlelp avtpeddgey wcvaenqygq ratafnlsve fapiillesh caaardtvqc lcvvksnpep svafelpsrn vtvneteref vysersglll tsiltlrgqa qapprvicts rnlygtqsle lpfqgahrlm wakigpdieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk

Gly20

Lyophilized

The predicted molecular weight of Recombinant Rat MAG is Mr 81 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 120 kDa.

81

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Ming, GL. et al. (2008) Molecular Brian 1: 10
2. Kelm, S. et al. (2001) FEBS Lett. 499: 262
3. Del Rio, JA. et al. (2005) Mol Cell Neurosci. 29: 471
4. Jay, DG. et al. (2003) J of Neurosci. 23: 3112