Anti-α1-Antichymotrypsin [Clone 1AC10-109.5]

Purified human serum alpha-1-antichymotrypsin.

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Upon initial thawing, appropriately aliquot and store at -20°C to -70°C. For long-term storage, keep at -20°C to -70°C. Avoid repeated freeze-thaw cycles.

Next Day 2-8°C

These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.

Alpha-1 antichymotrypsin (A1AC), an alpha globulin glycoprotein synthesized in the liver, belongs to the crucial serpin superfamily of protease inhibitors. In humans, the SERPINA3 gene is responsible for its production.

A1AC's primary role is to inhibit the activity of specific proteases by cleaving them into different conformations, thereby neutralizing their destructive potential. Key targets include cathepsin G from neutrophils and chymases from mast cells. This protective action is vital for safeguarding tissues, particularly in the lower respiratory tract, from damage caused by these proteolytic enzymes.

Beyond its role in protease inhibition, A1AC is recognized as an acute phase protein, meaning its levels increase significantly during periods of inflammation. Imbalances in A1AC can have serious health implications:

- Deficiency has been linked to liver disease.

- Mutations in the SERPINA3 gene have been identified in patients with conditions such as Parkinson's disease and chronic obstructive pulmonary disease (COPD).

- A1AC is also implicated in the pathogenesis of Alzheimer's disease, as it has been shown to enhance the formation of amyloid-fibrils, a hallmark of the disease.

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {PubMed:2404007}.