Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody – Library Pack (138101)

Alpha 1-antichymotrypsin (alpha1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. alpha1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. alpha1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils.

Purified human serum alpha-1-antichymotrypsin.

These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:

13801 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-109.5 - Isotype IgG2a

13802 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-118.2 - Isotype IgG1

13803 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-128.1 - Isotype IgG1

13804 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-143.1 - Isotype IgG2a

Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles.