Anti-α-1-antitrypsin Mouse Monoclonal Antibody – Library Pack (137101)

Alpha-1 Antitrypsin (alpha1AT) is a protease inhibitor of the serpin superfamily. It is generally known as serum trypsin inhibitor and is also referred to as alpha-1 proteinase inhibitor (alpha1PI) because it inhibits multiple proteases. It protects tissues from proteases of inflammatory cells, particularly neutrophil elastase, and has a reference range in blood of 1.5- 3.5 gram/liter, but the concentration can rise significantly in cases of acute inflammation. In its absence (such as in alpha1AT deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.

Purified human serum alpha-1-antitrypsin.

These antibodies specifically recognize human serum alpha-1-antitrypsin. They do not cross-react with alpha-1-antichymotrypsin.

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Anti-α-1-antitrypsin Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:

13701 - Anti-α-1-antitrypsin Mouse Monoclonal Antibody - Clone 1AT10-105.10 - Isotype IgG2a

13702 - Anti-α-1-antitrypsin Mouse Monoclonal Antibody - Clone 1AT11-210.1 - Isotype IgG1

13703 - Anti-α-1-antitrypsin Mouse Monoclonal Antibody - Clone 1AT11-209.3 - Isotype IgG1

13704 - Anti-α-1-antitrypsin Mouse Monoclonal Antibody - Clone 1AT11-213.5 - Isotype IgG1

Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles.