Anti-ß-Defensin-3 [Polyclonal]

Full-length human beta- defensin 3.

PBS, pH 7.4 with 0.02% sodium azide

Liquid

Purified by immunoaffinity chromatography

This antibody is stable for at least one (1) year at -20°C to -70°C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to beta-Defensin-3

Human beta-defensin-3 (hBD-3) is a unique, non-hemolytic antimicrobial peptide originally isolated from human psoriatic scales and cloned from keratinocytes. This potent peptide exhibits salt-insensitive, broad-spectrum antimicrobial activity against a wide range of pathogenic microbes, including multi-drug resistant S. aureus and vancomycin-resistant Enterococcus faecium. Found in keratinocytes and airway epithelial cells, hBD-3 expression can be induced by TNF-alpha and bacterial contact, suggesting its crucial role in the innate epithelial defense against infections in tissues like the skin and lungs (e.g., in conditions like cystic fibrosis).

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {PubMed:11085990}.