Anti-CLAC-P Antibody (28115)

Product No.: 28115


Target CLAC-P Product Type Polyclonal Alternate Names Alzheimer disease amyloid-associated protein, AMY, CLAC-P [Cleaved into: Collagen-like Alzheimer amyloid plaque component Applications IHC , WB


Select Product Size 100 µg — $397.00	Qty Max: Min: 1 Step: 1 $397.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities

Data

Immunohistochemistry (paraffin): at 510ug/ml


Antibody Details Product Details Reactive Species Human ⋅ Mouse Host Species Rabbit Immunogen Synthetic peptide corresponding to aa 430-445 of the NC3 region of human and mouse CLAC-P. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: at 2-5ug/mL, a band of approx. 70 kDa is detected in HEK293 cell lysate Immunohistochemistry (paraffin): at 5- 10ug/mL, positive staining of senile plaques in AD brains These are recommended concen- trations. User should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rabbit Polyclonal Antibody specific to CLAC-P Background Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (Abeta). Although production and deposition of Abeta appear closely related to the pathogenesis of AD, current evidence suggest that Abeta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta- amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens. Function Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {PubMed:15522881, PubMed:15615705, PubMed:15853808, PubMed:16300410}. NCBI Gene Bank ID COL25A1 UniProt.org Q9BXS0 Research Area Neuroscience References & Citations View product citations for antibody 28115 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

⋅

Mouse

Host Species

Rabbit

Immunogen

Synthetic peptide corresponding to aa 430-445 of the NC3 region of human and mouse CLAC-P.

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4.

State of Matter

Liquid

Product Preparation

Purified by immunoaffinity chromatography

Storage and Handling

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunoblotting: at 2-5ug/mL, a band of approx. 70 kDa is detected in HEK293 cell lysate

Immunohistochemistry (paraffin): at 5- 10ug/mL, positive staining of senile plaques in AD brains

These are recommended concen- trations. User should determine optimal concentrations for their applications.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Polyclonal Antibody specific to CLAC-P

Background

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (Abeta). Although production and deposition of Abeta appear closely related to the pathogenesis of AD, current evidence suggest that Abeta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta- amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.

Function

Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {PubMed:15522881, PubMed:15615705, PubMed:15853808, PubMed:16300410}.

NCBI Gene Bank ID

COL25A1

UniProt.org

Q9BXS0

Research Area

Neuroscience