Anti-HCV C1 [Polyclonal]

Product No.: 18604

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Target
Hepatitis C Virus
Product Type
Polyclonal
Isotype
Rabbit
Applications
WB

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Antibody Details

Product Details

Reactivity Species
Hepatitis C virus
Host Species
Rabbit
Immunogen
Peptide corresponding to amino acids 9-21 of Hepatitis C Virus (HCV) core protein C1.
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4 with 0.02% sodium azide
State of Matter
Liquid
Product Preparation
Purified by immunoaffinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
Immunoblotting: use at 1:500-1:1,000.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Polyclonal Antibody specific to Hepatitis C Virus
Background
The Hepatitis C Virus (HCV) core protein is a fascinating and crucial component of the HCV. It's formed from the first 191 amino acids of the virus's precursor polyprotein and gets inserted directly into the endoplasmic reticulum membrane during its creation. More than just a structural protein, the HCV core protein also actively participates in various cellular processes, including how genes are turned on and off (transcriptional regulation), though the exact mechanisms are still being unraveled.

It's believed that the HCV core protein significantly contributes to the development of HCV-related diseases by interacting with various signal transduction pathways within human cells. This protein has also been found circulating in the bloodstream of HCV-infected patients, where it can even inhibit the host's immune response through an interaction with a molecule called gC1qR. In fact, HCV core antigen has recently emerged as a valuable marker for detecting HCV infection.

Understanding the Hepatitis C Virus
HCV is a positive-sense, single-stranded RNA virus belonging to the Flaviviridae family. Its genome is approximately 10,000 nucleotides long and encodes a single large polyprotein of about 3,000 amino acids. This polyprotein is then precisely cut by both host cell and viral enzymes into three main structural proteins (including the core protein) and several non-structural proteins essential for the virus to replicate.

HCV is the primary cause of most non-A, non-B hepatitis cases. Unfortunately, a significant number of individuals infected with HCV go on to develop chronic infections, which can lead to severe liver damage, including cirrhosis and hepatocellular carcinoma (liver cancer). A hallmark of chronic HCV infection is the severe suppression of crucial immune responses, such as T cell responses and interferon-gamma production.

Antigen Details

Research Area
Infectious Disease

References & Citations

General Western Blot Protocol
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.