Anti-Human Annexin A1 Antibody (34050)
Anti-Human Annexin A1 Antibody (34050)
Product No.: 34050
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Clone G512.1 Target Annexin A1 Formats AvailableView All Product Type Monoclonal Alternate Names Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35 [Cleaved into: Annexin Ac2-26] Isotype Mouse IgG1 Applications IHC |
Data
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Recombinant human Annexin A1. Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling Store at 2-8°C. Do not freeze. Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to Annexin A1 Background Annexin A1 (ANXA1) is a membrane protein that plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandins, and leukotriene mediators. ANXA1 is overexpressed in 97% of samples from patients with hairy cell leukemia and is absent in other B-cell lymphomas. High ANXA1 expression is also associated with advanced stage esophageal and esophagogastric junction adenocarcinoma and has been linked to advanced and metastatic disease. Function Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {UniProtKB:P10107, UniProtKB:P19619, PubMed:17008549, PubMed:19625660, PubMed:2532504, PubMed:2936963, PubMed:8425544, PubMed:8557678}.; [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {PubMed:15187149, PubMed:22879591, PubMed:25664854}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & CitationsMikels A et al. 2009 J Biol Chem 284: 30167-30176.Wright TM et al. 2009 Oncogene 28: 2513-2523.Edris B et al. 2012 J Pathol 227: 223-233 |
Formats Available
