Anti-Human Apoptosis Repressor with CARD Domain (CT) (ARC)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Apoptosis Repressor with CARD Domain (CT) (ARC)

Pricing & Details

Product No.A159
Protein
Apoptosis Repressor with CARD Domain
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A159-20 µg
20 µg
$95.00
In stock
Max:
Min: 1
Step: 1
A159-0.1 mg
0.1 mg
$440.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:A177
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Apoptosis Repressor with CARD Domain (ARC) recognizes an epitope near the C-terminus of Human ARC. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD.1 ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.1

Antigen Details

References & Citations

1. Koseki, T. et al.(1998) Proc Natl Acad Sci U S A 95:5156-60
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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