Anti-Human Bcl-G

Product No.: B448

[product_table name="All Top" skus="B448"]

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Target
Bcl-G
Product Type
Polyclonal Antibody
Alternate Names
Bcl-2-like 14
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:B474
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Bcl-G recognizes human, mouse and rat Bcl-G. This polyclonal antibody was purified using affinity chromatography.
Background
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain.1,2 BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G.3 The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.3

Antigen Details

PubMed

References & Citations

1. Cory, S. et al. (2003) Oncogene 22:8590-607.
2. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35.
3. Guo, B. et al. (2000) J. Biol. Chem. 276:2780-5.
IHC FFPE
General Western Blot Protocol
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Prod No.
Description
B448
B474
Products are for research use only. Not for use in diagnostic or therapeutic procedures.