Anti-Human BMI-1 (Intermediate Domain)

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Pricing & Details

Product No.B481
Protein
BMI-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Polycomb Group RING Finger Protein 4, RNF51
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B481-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B481-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B501
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human BMI-1 recognizes an epitope in the intermediate domain of human, mouse and rat BMI-1. This polyclonal antibody was purified using affinity chromatography.
Background
The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence.2 Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells,3 suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.

Antigen Details

Protein
PubMed

References & Citations

1. Alkema, MJ. et al. (1993) Hum. Mol. Genet. 2:1597
2. Jacobs, J J. et al. (1999) Nature 397:164
3. Lessard, J. et al. (2003) Nature 255
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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