Anti-Human BTK (NT)

PN:B513

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human BTK recognizes an epitope near the N-terminus of Human and Mouse BTK. This polyclonal antibody was purified using affinity chromatography.

Bruton’s tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked aγ-globulinaemia (1), and has since been shown to involved in a number of signaling pathways in hemapoietic lineage (reviewed in 2). It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9 (3). The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens (reviewed in 4). BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction (3).

1. Vetrie, D. et al. (1993) Nature 361:226
2. Kawakami, Y. et al. (1999) Biol. 65(3):286
3. Jefferies, CA. et al. (2003) Biol. Chem. 278:26258
4. Akira, S. et al. (2004) Nat. Rev. Immunol. 4:499