Anti-Human BTK (NT)

Anti-Human BTK (NT)

Product No.: B518

[product_table name="All Top" skus="B518"]

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Target
BTK
Product Type
Polyclonal Antibody
Alternate Names
Bruton’s Tyrosine Kinase, Agammaglobulinaemia Tyrosine Kinase, ATK, BPK
Applications
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:B513
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human BTK recognizes an epitope near the N-terminus of Human and Mouse BTK. This polyclonal antibody was purified using affinity chromatography.
Background
Bruton’s tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked aγ-globulinaemia (1), and has since been shown to involved in a number of signaling pathways in hemapoietic lineage (reviewed in 2). It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9 (3). The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens (reviewed in 4). BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction (3).

Antigen Details

PubMed

References & Citations

1. Vetrie, D. et al. (1993) Nature 361:226
2. Kawakami, Y. et al. (1999) Biol. 65(3):286
3. Jefferies, CA. et al. (2003) Biol. Chem. 278:26258
4. Akira, S. et al. (2004) Nat. Rev. Immunol. 4:499
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.