Anti-Human CARD10 (CT)

Pricing & Details

Product No.C1215
Protein
CARD10
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Caspase Recruitment Domain Family Member 10, CARMA3, Bimp1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1215-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1215-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1227
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase Recruitment Domain Family Member 10 (CARD10) recognizes an epitope near the C-terminus of human and mouse CARD10. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10.1 This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.2 CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-κB.1,3 CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IκK complex,4 demonstrating its importance in the regulation of NF-κB transcription factor activation.

Antigen Details

Protein
PubMed

References & Citations

1. Wang, L. et al. (2001) J. Biol. Chem. 276:21405-9.
2. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9.
3. Fischer, KD. et al. (2004) Trends Immunol. 25:113-6.
4. Stilo, R. et al. (2004) J. Biol. Chem. 279:34323-31.
IHC
General Western Blot Protocol
Prod No.
Description
C1227
C1215
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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