Anti-Human Casp-5 (NT)

Pricing & Details

Product No.C1230
Protein
Caspase-5
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
ICH-3, ICE rel III
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1230-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1230-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1272
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Casp-5 recognizes an epitope near the N-terminus of Human Casp-5. This polyclonal antibody was purified using affinity chromatography.
Background
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.1 Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.2,3 Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β.4

Antigen Details

Protein
PubMed

References & Citations

1. Martinon, F. and Tschopp, J. (2004) Cell. 117(5):561-74.
2. Kuida, K. et al. (1995) Science. 267(5206):2000-3.
3. Gracie, JA. et al. (2003) J Leukoc Biol. 73(2):213-24.
4. Martinon, F. et al. (2002) Mol Cell. 10(2):417-26.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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