Anti-Human Caspase-14 (CT)

Anti-Human Caspase-14 (CT)

Product No.: C1249

[product_table name="All Top" skus="C1249"]

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Product Type
Polyclonal Antibody
Alternate Names
Mini-interleukin-1 converting enzyme, Mini-ICE, MICE

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Antibody Details

Product Details

Reactive Species
Host Species
Product Concentration
0.5 mg/ml
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.


Rabbit Anti-Human Caspase-14 recognizes an epitope near the C-terminus of mouse, rat and human Caspase-14. This polyclonal antibody was purified using affinity chromatography.
Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Antigen Details

References & Citations

1. Martinon, F. and Tschopp, J.(2004) Cell 117:561-74.
2. Zhivotovsky, B. and Orrenius, S. (2005) Biophys. Res. Comm. 331:859-67.
3. Flavell, RA. et al. (1995) Science 267:2000-3.
4. Gracie, JA. et al. (2003) J. Leukoc. Biol. 73:213-24.
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.