Anti-Human Caspase-14 (CT)

Pricing & Details

Product No.C1249
Protein
Caspase-14
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Mini-interleukin-1 converting enzyme, Mini-ICE, MICE
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1249-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1249-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1287
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase-14 recognizes an epitope near the C-terminus of mouse, rat and human Caspase-14. This polyclonal antibody was purified using affinity chromatography.
Background
Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Antigen Details

Protein

References & Citations

1. Martinon, F. and Tschopp, J.(2004) Cell 117:561-74.
2. Zhivotovsky, B. and Orrenius, S. (2005) Biophys. Res. Comm. 331:859-67.
3. Flavell, RA. et al. (1995) Science 267:2000-3.
4. Gracie, JA. et al. (2003) J. Leukoc. Biol. 73:213-24.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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