Anti-Human CD57 Antibody (34054)

Product No.: 34054

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Clone
G539.1
Target
CD57
Formats AvailableView All
Product Type
Monoclonal
Alternate Names
EC 2.4.1.135, β-1,3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein β-1,3-glucuronyltransferase, GlcUAT-P
Isotype
Mouse IgG1
Applications
IHC

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Data

Immunohistochemistry: Detection of CD57 in Hodgkin’s Lymphoma with #34054 diluted 1:100-1:200.
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Recombinant human CD57.
Formulation
Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.
State of Matter
Liquid
Product Preparation
Purified by immunoaffinity chromatography
Storage and Handling
Store at 2-8°C. Do not freeze.
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco


Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Mouse Monoclonal Antibody specific to CD57
Background
It was originally believed that CD57 (cluster of differentiation 57) was uniquely expressed on natural killer (NK) cells, but further research showed that CD57 was expressed only on a subset of functionally distinct NK cells. CD57 was subsequently identified on CD8+ T cells as well as on cells of neural crest origin. In neural cells, the CD57 epitope is predominantly restricted to adhesion molecules. CD57 has been utilized as a marker for tumors of neuroendocrine origin including pheochromocytomas, paragangliomas, carcinoid tumors, medulloblastomas, neuromas, neurofibromas, schwannomas, and granular cell tumors. Expression of CD57 can be used to distinguish nodular lymphocyte-predominant Hodgkin's lymphoma from T-cell/histiocyte-rich large B-cell lymphoma, nodular sclerosis, Hodgkin's disease, and follicular lymphoma.
Function
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. {UniProtKB:O35789}.
NCBI Gene Bank ID
UniProt.org
Research Area
Cancer Research

References & Citations

Formats Available

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Prod No.
Description
34054
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.