Anti-Human Cytokeratin 18 Antibody (34058)

Product No.: 34058


Clone G018.1 Target Cytokeratin 18 Formats AvailableView All Product Type Monoclonal Alternate Names Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18 Isotype Mouse IgG1 Applications IHC


Select Product Size 100μl — $201.00	Qty Max: Min: 1 Step: 1 $201.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities

Data

Immunohistochemistry: Detection of Cytokeratin 18 in human breast carcinoma with #34058 diluted 1:100-1:200.


Antibody Details Product Details Reactive Species Human Host Species Mouse Immunogen Recombinant human Cytokeratin 18. Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling Store at 2-8°C. Do not freeze. Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Mouse Monoclonal Antibody specific to Cytokeratin 18 Background Cytokeratin 18 is a type I cytokeratin. Together with its filament partner cytokeratin 8, it is perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues. Mutations in this gene have been linked to cryptogenic cirrhosis. Multimers of cytokeratin 18 and cytokeratin 8 are present in simple, glandular, and transitional epithelial cells, but absent from stratified epithelial cells, and are found in adenocarcinomas of simple and glandular epithelium origin and poorly differentiated squamous carcinoma cells. Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {PubMed:15529338, PubMed:16424149, PubMed:17213200, PubMed:7523419, PubMed:8522591, PubMed:9298992, PubMed:9524113}. NCBI Gene Bank ID KRT18 UniProt.org P05783 Research Area Cancer Research References & Citations View product citations for antibody PRODUCT_CODE on CiteAb Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

Recombinant human Cytokeratin 18.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

State of Matter

Liquid

Product Preparation

Purified by immunoaffinity chromatography

Storage and Handling

Store at 2-8°C. Do not freeze.

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Monoclonal Antibody specific to Cytokeratin 18

Background

Cytokeratin 18 is a type I cytokeratin. Together with its filament partner cytokeratin 8, it is perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues. Mutations in this gene have been linked to cryptogenic cirrhosis. Multimers of cytokeratin 18 and cytokeratin 8 are present in simple, glandular, and transitional epithelial cells, but absent from stratified epithelial cells, and are found in adenocarcinomas of simple and glandular epithelium origin and poorly differentiated squamous carcinoma cells.

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {PubMed:15529338, PubMed:16424149, PubMed:17213200, PubMed:7523419, PubMed:8522591, PubMed:9298992, PubMed:9524113}.

NCBI Gene Bank ID

KRT18

UniProt.org

P05783

Research Area

Cancer Research