Anti-Human DAPK2

Pricing & Details

Product No.D256
Protein
DAPK2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Death-Associated Protein Kinase 2
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D256-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D256-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D261
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DAPK2 recognizes an epitope near the C-terminus of mouse, rat and human DAPK2. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1.1,2 Ectopicly expressed DAPK2 induced apoptosis in various types of cells.1,2 DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues.1

Antigen Details

Protein
PubMed

References & Citations

1. Kawai, T. et al. (1999) Oncogene 18(23):3471-80
2. Inbal, B. et al. (2000) Mol Cell Biol 20(3):1044-54
IHC
General Western Blot Protocol
Prod No.
Description
D256
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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