Anti-Human DcR3 (NT)

Pricing & Details

Product No.D255
Protein
DcR3
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
TR6, Decoy Receptor 3 Precursor
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D255-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D255-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D267
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DcR3 recognizes an epitope near the N-terminus of mouse, rat and human DcR3. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively.1,2 Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis.1,2 DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

Antigen Details

Protein
PubMed

References & Citations

1. Pitti, RM. et al. (1998) Nature 396:699-703
2. Yu, KY. et al. (1999) J Biol Chem274:13733-6
IHC
General Western Blot Protocol
Prod No.
Description
D267
D255
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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