Anti-Human DDX3 (NT)

Anti-Human DDX3 (NT)

Product No.: D326

[product_table name="All Top" skus="D326"]

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Target
DDX3
Product Type
Polyclonal Antibody
Alternate Names
Dead Box Polypeptide 3 X-Linked, DBX, Helicase-Like Protein 2
Applications
IHC FF
,
IHC FFPE
,
WB

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DDX3 recognizes an epitope near the N-terminus of Human and Mouse DDX3. This polyclonal antibody was purified using affinity chromatography.
Background
DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases.1,2 DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome.3 DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation.4 It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

Antigen Details

PubMed

References & Citations

1. Linder, P. et al. (1989) Nature 337:121 2. Park, S. H. et al. (1998) Cytogenet. Cell Genet. 81:178 3. Lahn, B. T. et al. (1997) Science 278:675 4. Abdelhaleem, M. (2005) Clin. Biochem. 38:499
IHC FF
IHC FFPE
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.