Anti-Human IL-1 Receptor Associated Kinase M (IRAK-M)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human IL-1 Receptor Associated Kinase M (IRAK-M)

Pricing & Details

Product No.I-310
Protein
IRAK-M
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Interleukin-1 Receptor Associated Kinase M
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
I-310-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
I-310-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:I-322
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human IL-1 Receptor Associated Kinase M (IRAK-M) recognizes Human, Mouse and Rat IRAK-M. This polyclonal antibody was purified using affinity chromatography.
Background
Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-βB by IL-1/Toll receptors,1,2 which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M.3 IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-βB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

Antigen Details

Protein
PubMed

References & Citations

1. Cao, Z. et al. (1996) Science 271:1128
2. Muzio, M. et al. (1997) Science 278:1612
3. Wesche, H. (1999) J. Biol. Chem. 274(27):19403
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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