Anti-Human IRF8 (CT)

PN:I-520

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human Interferon Regulatory Factor-8 (IRF8) recognizes an epitope near the C-terminus of Human, Mouse and Rat IRF8. This polyclonal antibody was purified using affinity chromatography.

Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-α/β genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases,^2,3 but IRF8 mediates activation of NF-κB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells.⁴ Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439 2. Weisz, A. et al. (1992) J. Biol. Chem. 267:25589 3. Nelson, N. et al. (1993) Mol. Cell. Biol. 13:588 4. Tsujimura, H. et al. (2004) J. Immunol. 172:6820